GPC is most strongly linked to wear of which lens material?

GPC is most strongly linked to wear of which lens material?

• A. Daily wear hydrogel
• B. Silicone hydrogel
• C. Rigid gas permeable
• D. Glasses

Answer: (B)

Giant papillary conjunctivitis is driven by chronic mechanical irritation and antigen exposure from contact lens wear, especially when the lens surface accumulates deposits that irritate the palpebral conjunctiva. Among common lens materials, silicone hydrogel lenses are most strongly linked to this reaction because their surface properties can promote tear film deposits (protein, lipid, mucin) and increased lid–lens interaction during blinking. These factors repeatedly stimulate the upper tarsal conjunctiva, leading to the large papillae and itching characteristic of GPC. Daily wear hydrogel can cause it as well, but the association is strongest with silicone hydrogel lenses; rigid gas-permeable lenses and glasses are far less likely to provoke this specific papillary response.

Giant papillary conjunctivitis is driven by chronic mechanical irritation and antigen exposure from contact lens wear, especially when the lens surface accumulates deposits that irritate the palpebral conjunctiva. Among common lens materials, silicone hydrogel lenses are most strongly linked to this reaction because their surface properties can promote tear film deposits (protein, lipid, mucin) and increased lid–lens interaction during blinking. These factors repeatedly stimulate the upper tarsal conjunctiva, leading to the large papillae and itching characteristic of GPC. Daily wear hydrogel can cause it as well, but the association is strongest with silicone hydrogel lenses; rigid gas-permeable lenses and glasses are far less likely to provoke this specific papillary response.